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The Australian government mammography screening program offers free routine mammography screening each two years for women between 50-75 years, and provides screening outside these limits on request and in high-risk circumstances. Films are reviewed by trained radiologists and clinical assessment performed on recall by specialist breast surgeons. Aims are to identify lesions at an earlier stage, before the tumours are clinically apparent; and treatment of screen-detected early cases of breast cancer has been demonstrated to give improved survival. The main abnormalities detected on screening are: • focal parenchymal lesions and asymmetries • abnormal (dystrophic) calcification typical of benign lesions (fibroadenoma, mammary duct ectasia, vascular calcification) • abnormal (dystrophic) calcification suspicious of malignancy. Calcification occurs in abnormal ductal cells and within the ducts, or within breast stroma. Several distinctive patterns are recognisable. • Calcification suspicious of invasive breast carcinoma. Where focal microcalcification is associated with parenchymal asymmetry and distortion, with punctuate calcification within a spiculated focal mass, showing irregular margins and radiating parenchymal infiltration around the mass lesion, the diagnosis is most likely to be an invasive carcinoma of the breast. Some of these screening-identified lesions will be palpable, but in large breasts with small lesions will be impalpable. Image-guided core biopsy to confirm the diagnosis will be followed by excisional surgery which can often be breast-conserving wide local excision, axillary surgery of sentinel node biopsy or axillary clearance, local irradiation to the remaining breast tissue and adjuvant therapy as determined by hormone receptor status (ER,PR, Herceptin) and staging. • Clearly benign calcification. This includes focal macrocalcification in discrete, and often large, dense blobs of calcium, often within a focal discrete mass lesion with regular borders and ultrasonic benign shadowing - these findings are characteristic of benign fibroadenomas. They are found at all ages, including elderly patients. The lesions have no propensity for malignant change and can be observed by routine recall mammography, avoiding, requirement for biopsy or excision. • Linear focal intraduct calcification. This is typical of benign plasma cell mastitis (mammary duct ectasia, 'spilt milk mastitis') where calcium is dispersed throughout inspissated ductal secretions, often showing horizontal fluid levels altering with posture and decubitus effects. These lesions are also benign, without pre-malignant potential, and can also be observed by routine recall mammography. • Vascular calcification within walls of arteries has a characteristic pattern and is, again, entirely benign. • Clearly malignant or highly suspicious of malignancy. Ductal carcinoma in situ (DCIS), and also lobular carcinoma in situ (LCIS), can give classically malignant calcification in necrotic tumour cells within ducts. These give irregular areas of focal or widespread microcalcification, as distinct from macrocalcification, with appearances analogous to irregular crushed rock fragments, or branching short-chain segments. Focal punctate microcalcification association with invasive cancer gives similarly heterogeneous calcification, often in association with a stellate spiculated parenchymal mass lesion with irregular margins. In this instance the irregular focal microcalcification is highly suggestive of ductal malignancy, which may be ductal carcinoma in situ (DCIS) or an invasive ductal carcinoma (B is correct). ~ Such highly suspicious calcifications require confirmatory diagnosis by percutaneous needle core biopsy, followed by appropriate surgical excision and adjuvant treatment. ~ Another large group includes those with calcification of indeterminate type without definitive features of malignancy, but not typical of benign lesions. These lesions all require further imaging and, if the diagnosis remains in doubt, diagnostic core biopsy. Cystosarcoma phyllodes (Brodie serocystic disease) is an uncommon tumour with characteristic 'leafy' (phyllodes) and cystic morphology, without specific features of calcification. The tumours show a spectrum of malignancy from local invasion to metastatic spreading lesions. Fat necrosis after trauma can cause focal fibrosis and parenchymal distortion, and may be associated with clearly benign dystrophic calcification, or occasionally calcification of indeterminate type requiring diagnostic biopsy. A further example is illustrated of multifocal breast carcinoma with spiculated focal densities, with confirmation of diagnosis by percutaneous core biopsies. Optimal treatment in such instances is by total mastectomy for local control. (缺图)